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Zirconium catalyzed amide formation without water scavenging
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Number of Authors: 32019 (English)In: Applied organometallic chemistry, ISSN 0268-2605, E-ISSN 1099-0739, Vol. 33, no 9, article id e5062Article in journal (Refereed) Published
Abstract [en]

A scalable homogeneous metal-catalyzed protocol for direct amidation of carboxylic acids is presented. The use of 2-10 mol% of the commercially available Zr(Cp)(2)(OTf)(2)center dot THF results in high yields of amides at moderate temperature, using an operationally convenient reaction protocol that circumvents the use of water scavenging techniques.

Place, publisher, year, edition, pages
2019. Vol. 33, no 9, article id e5062
Keywords [en]
mides, amines, carboxylic acids, catalysis, direct amidation, trifluoromethanesulfonate, zirconium
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-171723DOI: 10.1002/aoc.5062ISI: 000476374900001OAI: oai:DiVA.org:su-171723DiVA, id: diva2:1350407
Available from: 2019-09-11 Created: 2019-09-11 Last updated: 2022-03-23Bibliographically approved

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Lundberg, HelenaAdolfsson, Hans

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