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Nickel-Catalyzed Stereospecific Deoxygenation of trans- Aromatic Epoxides to (Z)-Alkenes: An Efficient Route to Access (Z)-Cinnamic Acid Derivatives
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0001-8735-5397
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Number of Authors: 62024 (English)In: Asian journal of organic chemistry, ISSN 2193-5807, Vol. 13, no 5, article id e202400009Article in journal (Refereed) Published
Abstract [en]

A stereospecific deoxygenation of trans-epoxy cinnamic acid derivatives to access (Z)-cinnamamides, (Z)-cinnamyl alcohol and (Z)-cinnamyl amines using a catalytic system based on nickel triflate and triphenylphosphine has been developed. The desired products were obtained in good to excellent yield (up to 92 % isolated yield) and excellent stereospecificity (Z: E ratio up to>99: 1). The transformation has a broad functional group tolerance including amides, amines, alcohols and esters. The power of the methodology was demonstrated in the key step of the total synthesis of biologically active natural product, N-cis-feruloyl tyramine from readily available trans-ferulic acid. A reaction mechanism involving activation of epoxide via coordination of the oxygen atom and the neighboring O- or N-atoms to the nickel catalyst and formation of Ph3P-carbon bond is proposed. This method is important for synthesis of highly desirable functionalized (Z)-alkenes from readily available (E)-alkenes.

Place, publisher, year, edition, pages
2024. Vol. 13, no 5, article id e202400009
Keywords [en]
deoxygenation, epoxide, stereospecific, cinmanamide, cinnamyl
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-228102DOI: 10.1002/ajoc.202400009ISI: 001179435800001Scopus ID: 2-s2.0-85186400403OAI: oai:DiVA.org:su-228102DiVA, id: diva2:1851941
Available from: 2024-04-16 Created: 2024-04-16 Last updated: 2024-11-05Bibliographically approved

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Samec, Joseph S. M.

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