The IceCube Neutrino Observatory has the invaluable capability of continuously monitoring the whole sky. This has affirmed the role of IceCube as a sentinel, providing real-time alerts to the astrophysical community on the detection of high-energy neutrinos and neutrino flares from a variety of astrophysical sources. As a response to the IceCube alerts, different observatories can join forces in the multi-messenger observation of transient events and the characterisation of their astrophysical sources. The 2017 breakthrough identification of blazar TXS 0506+056 as the source of high-energy neutrinos and UHE gamma rays was proof of this strategy. The Gamma-ray Follow-Up (GFU) is the IceCube program for identifying high-energy muon neutrino single events, as well as outstanding neutrino flares from relevant sources and the whole wide universe. While the identification of single high-energy neutrinos is shared on public alert distribution networks, partner Imaging Air Cherenkov Telescopes are sent low-latency alerts following the detection of neutrino flares, for which they have dedicated follow-up programs. I will present an overview of the GFU platform together with new results from the analysis of recorded neutrino flares, after a dozen years of GFU operation and hundreds of alerts being sent.