Aim: The COVID-19 pandemic and associated restrictions posed challenges to people’s private and work lives. This included a rapid shift from on-site to remote work for many working adults in Sweden and internationally, and limited opportunities for indoor social and leisure activities. This involved risks for increased loneliness and social isolation, particularly among those mainly working remotely. In this context, nature visits may mitigate loneliness. This study adds to existing research in investigating whether a higher degree of remote work during COVID-19 was related to increased loneliness and whether nature visits mitigated loneliness, especially for those who mainly worked remotely. Subject and methods: The sample comprised a subsample of respondents to the Swedish Longitudinal Occupational Survey of Health 2020 (n = 984). Nature-related habits (NRH) were measured using self-reported frequency of visits to various natural environments. The effect of remote work, NRH, and time on loneliness (before – during COVID-19) was analyzed using linear mixed models while controlling for confounders. Results: Loneliness levels during COVID-19 were highest and increased the most compared to before the pandemic among individuals with the greatest degree of working remotely. Engaging daily in NRH was associated with lower loneliness levels, particularly among individuals mostly working remotely. This was observed in a three-way interaction effect between remote work, NRH, and time on loneliness. Conclusion: Daily nature visits may protect against loneliness during and beyond crises like COVID-19, particularly for those mainly working remotely. Policies preserving and facilitating access to nature may promote resilience during and beyond crises like COVID-19.