Core-collapse supernovae (SNe) provide a unique environment to study feebly interacting particles (FIPs) such as axionlike particles (ALPs), sterile neutrinos, and dark photons (DPs). This paper focuses on heavy FIPs produced in SNe, whose decay produces electrons and positrons, generating observable secondary signals during their propagation and annihilation. We focus on the in-flight annihilation of positrons, which emerge as the most significant contribution to the resulting 𝛾-ray spectrum. Using data from COMPTEL and EGRET, we derive the most stringent bounds on the FIP-electron couplings for heavy ALPs, sterile neutrinos, and DPs. These results strengthen existing bounds by one to two orders of magnitude, depending on the FIP model.