Effective area-based conservation is central in global efforts to reverse marine biodiversity loss and safeguard ecosystem functioning. Here, we identify five key opportunities to maximize conservation potential as nations progress towards the Convention on Biological Diversity’s 2030 area-based management targets. These include enhancing accountability, elevating conservation in spatial planning, implementing adaptive management, coordinating conservation efforts across scales, and reconciling design with expected outcomes. Addressing these collectively will advance global marine conservation and maximize its contributions to biodiversity protection and human society.